Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression.
- Author:
Rui YANG
1
;
Xiao-ping WU
;
Xiao-ying BAI
;
Wen-de NING
;
Jun-le YANG
;
Zhi-chuan XIE
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Case-Control Studies; Choline; metabolism; Creatine; metabolism; Depression; diagnosis; Female; Humans; Hypothalamus; metabolism; Inositol; metabolism; Magnetic Resonance Spectroscopy; methods; Male; Middle Aged; Protons; Thalamus; metabolism; Young Adult
- From: Journal of Southern Medical University 2009;29(12):2442-2445
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the presence of abnormal metabolism in the thalamus and hypothalamus in patients with first-episode depression.
METHODSThirty drug-naive patients with first-episode depression and 30 age-matched controls were scanned with proton magnetic resonance spectroscopy ((1)H-MRS) for Naa, Cho, Cr and mI.
RESULTSCompared with the control group, the patients showed significantly reduced mI and mI/Cr of the hypothalamus, reduced mI/Cr of the left thalamus, and lowered Cho, ml, and ml/Cr of the right thalamus (P<0.05).
CONCLUSIONPatients with first-episode depression may have myo-inositol and phosphoric acid metabolism disorder in the thalamus and hypothalamus with malfunction of cellular osmotic pressure adjustment mechanism. Abnormal mI/Cr in the thalamus and hypothalamus may represent an important biochemical change in advanced patients with depression.
