Study on semi-synthetic transforming technology for the natural product of isocorydione.
- Author:
Tian-Cai ZHANG
1
;
He-Lin YE
;
Jun-Xi LIU
;
Duo-Long DI
Author Information
1. School of Pharmay, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemical synthesis;
chemistry;
isolation & purification;
Aporphines;
chemical synthesis;
chemistry;
isolation & purification;
Crystallography, X-Ray;
Hydrogen-Ion Concentration;
Molecular Structure;
Nitroso Compounds;
Oxidation-Reduction;
Papaveraceae;
chemistry;
Plants, Medicinal;
chemistry;
Spectrophotometry, Ultraviolet;
Temperature;
X-Ray Diffraction
- From:
Acta Pharmaceutica Sinica
2011;46(12):1471-1475
- CountryChina
- Language:Chinese
-
Abstract:
Transforming technology for semi-synthesized isocorydione from the natural product ofisocorydine was studied. The factors affecting on the reaction yield were investigated. UV spectrophotometry was used to indicate the semi-synthesized yield of isocorydione. The optimum reaction conditions were determined as following: reacting for 12 h in the solution of sodium dihydrogen phosphate at pH 10, the temperature was 25 degrees C and the ratio of isocorydine to Fremy's radical was 1 : 2. Under the optimum conditions, the yield could reach up to 50.0%. The molecular structure of isocorydione was elucidated by X-ray single-crystal diffraction analysis for the first time.
