Effect of c-Met inhibitor SU11274 on human colon cancer cell growth.
- Author:
Shuo-hui GAO
1
;
Chao LIU
;
Jun WEI
;
Ye FENG
Author Information
- Publication Type:Journal Article
- MeSH: Cell Cycle; drug effects; Cell Line, Tumor; Cell Proliferation; drug effects; Colonic Neoplasms; drug therapy; pathology; Hepatocyte Growth Factor; pharmacology; Humans; Indoles; pharmacology; Piperazines; pharmacology; Proto-Oncogene Proteins c-met; antagonists & inhibitors; physiology; Signal Transduction; Sulfonamides; pharmacology
- From: Chinese Medical Journal 2013;126(14):2705-2709
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDColon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy. Downregulation of HGF/c-Met signaling pathway is an emerging therapy for cancer treatment.
METHODSIn this study, the inhibitory effects of c-Met phosphorylation were observed with SU11274 on different colon cancer cell lines in vitro.
RESULTSThe results revealed the significant inhibitory effects of SU11274 on cell proliferation and cell survival, in a time and dose-dependent manner. Furthermore, the inhibitory effects of SU11274 on different subgroups of colon cancer cells via the HGF/c-Met signaling pathway were implicated in this study.
CONCLUSIONThe results suggested the possible selective therapeutic effects of c-Met inhibitor on colon cancer.
