Overall intestinal permeability of multiple components in lotus leaves.
- Author:
Cheng-Bo HOU
1
;
Yue-Liu DONG
1
;
Xiu-Wen YIN
1
;
Yang LIU
1
;
Hui-Juan SUN
1
;
Ying-Ying CHEN
1
;
Ling DONG
1
Author Information
- Publication Type:Journal Article
- Keywords: HPLC; biopharmaceutics classification system of Chinese materia medica; in vitro everted gut sac; lotus leaf; permeability
- From: China Journal of Chinese Materia Medica 2016;41(7):1183-1187
- CountryChina
- Language:Chinese
- Abstract: In the study of biopharmaceutics classification system of Chinese materia medica (CMMBCS), the interactions of multiple components in the absorption should be taken into consideration in simultaneous multi-component determination. To investigate the absorption of multiple components, the in vitro everted gut sac model was used in this study, wtih lotus leaves as the research object. Aquantitative analysis was also carried out for the known components in this study. Totally 19 components in lotus extracts were absorbed by the intestinal tract, the Papp levels of the known components were nuciferine (1×10⁻⁵-1×10⁻⁶ cm•s⁻¹), rutin (1×10⁻⁶-1×10⁻⁷ cm•s⁻¹), hyperoside (1×10⁻⁶ cm•s⁻¹), isoquercitrin (1×10⁻⁶-1×10⁻⁷ cm•s⁻¹) and astragalin (1×10⁻⁶-1×10⁻⁷ cm•s⁻¹), respectively. These components showed a low permeability under a multi-component environment. This study was carried out to lay a foundation for further relevant target studies for different categories of components.
