Prognostic significance of γ-H2AX in laryngeal squamous cell carcinoma after surgery.
- Author:
Jingyi ZHANG
1
;
Lei CHENG
1
;
Liang ZHOU
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; metabolism; pathology; surgery; Female; Head and Neck Neoplasms; metabolism; pathology; surgery; Histones; metabolism; Humans; Immunohistochemistry; Laryngeal Neoplasms; diagnosis; metabolism; pathology; surgery; Male; Middle Aged
- From: Chinese Medical Journal 2014;127(14):2664-2667
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDThe clinical significance of γ-H2AX in laryngeal squamous cell carcinoma (LSCC) has not yet been established. This study was performed to assess the expression of nuclear γ-H2AX in benign and malignant laryngeal lesions and to assess its clinicopathological significance.
METHODSA total of 70 LSCC tumor-normal tissue paired samples were evaluated for γ-H2AX expression using immunohistochemical staining. Their expression was correlated with different clinicopathological parameters.
RESULTSNuclear γ-H2AX expression was frequently detected in LSCC tissues (P < 0.001). High nuclear γ-H2AX levels were not associated with any clinicopathological characteristics of LSCC (P > 0.05). Univariate Kaplan-Meier analysis showed that positive nuclear γ-H2AX expression was associated with a decreased overall survival (P = 0.017). Multivariate Cox regression analysis showed that nuclear γ-H2AX expression was an independent risk factor for overall survival.
CONCLUSIONThe expression of nuclear γ-H2AX might be closely related to the prognosis of LSCC.
