Investigation of the characteristics of HCV genotypes of han and korean In yanbian area of Jilin province
10.3760/cma.j.issn.1003-9279.2010.02.009
- VernacularTitle:吉林省延边地区朝鲜族与汉族HCV基因型特征分析
- Author:
Zhong-Xie LI
1
;
Fan-Ping MENG
;
Gang-Tie SHEN
;
Dan JIN
;
Xiang-Wei FENG
Author Information
1. 珲春市医院
- Keywords:
Hepacivirus;
Genotype;
Ethnic groups
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(2):104-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of HCV genotypes of Han and Korean in Yanbian area of Jilin Province.Methods The HCV RNA load and genotypes of the 119 chronic hepatitis C patients in Yanbian area of Jilin Province were determined by real-time PCR and LiPA.The differences of the HCV genotypes in Han and Korean cases,in severity of the diseases,in HCV-RNA load,and in the relation with type 2 diabetes mellitus were analyzed.Results There was no significant difference in the distribution of each HCV genotype between Han and Korean patients (P＞0.05) with chronic hepatitis C.The difference between HCV genotype and HCV-RNA load was not significant (P＞0.05).With and without type 2 diabetes mellitus in these patients.The distribution of HCV genotype was also not significandy different (P＞0.05).The type 1b of HCV genotype in the moderate to severe chronic hepatitis C patients accounted for 58.06%.It was different compared with mild chronic hepatitis C patients (P＜0.05).Conclusion ①The type 1b is the most popular HCV genotype in Yanbian area of Jilin Province,type 2a is the second and there are still a few other genotypes.②There is no significant difference in the distribution of HCV genotypes between Han and Korean cases.③The HCV genotypes has nothing to do with the load of HCV-RNA.④The distribution of HCV genotypes in chronic hepatitis C patients with and without diabetes mellitus is not significantly different.⑤Type 1b of HCV infection is relatively severe.
