Expression of BCL-10 protein and the relationship with API2-MALT1 fusion gene in extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue.
- Author:
Lei LI
1
;
Gan-di LI
;
Wei JIANG
;
Wen-xiu YANG
;
Wei-ping LIU
;
Wen-yan ZHANG
;
Ji-man LI
;
Yuan TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adaptor Proteins, Signal Transducing; genetics; metabolism; B-Cell CLL-Lymphoma 10 Protein; Cell Nucleus; metabolism; Cytoplasm; metabolism; Female; Follow-Up Studies; Gastric Mucosa; metabolism; pathology; Hashimoto Disease; genetics; metabolism; pathology; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphoid Tissue; metabolism; pathology; Lymphoma, B-Cell, Marginal Zone; genetics; metabolism; pathology; Male; Middle Aged; Oncogene Proteins, Fusion; genetics; metabolism; Respiratory Mucosa; metabolism; pathology; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Oncology 2006;28(9):678-682
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of BCL-10 protein and API2-MALT1 fusion gene in MALT lymphoma.
METHODSSpecimens from 86 cases of MALT lymphoma were studied by immunohistochemical staining for BCL-10. RT-PCR was used to detect the transcripts of API2-MALT1 fusion gene.
RESULTSIn all 10 cases of Hashimoto thyroiditis only cytoplasmic BCL-10 expression in lymphoid cells was observed. In 86 MALT lymphoma cases, 42 cases (48. 8%) exhibited BCL-10 expression in both nucleus and cytoplasm. API2-MALT1 fusion gene was detected in 35 cases (40. 7%) of MALT lymphoma. BCL-10 nuclear expression was correlated with API2-MALT1 fusion gene transcript (r = 0. 374,P = 0. 000).
CONCLUSIONBCL-10 nuclear expression is correlated with API2-MALT1 fusion gene expression in MALT lymphoma.
