Studies on chemical constituents in heartwood of Taxus cuspidata.
- Author:
Cong-Mei CAO
1
;
Chang-Hong HUO
;
Yong-Ming ZHAO
;
Xiao-Tang SI
;
Zuo-Ping LI
;
Qing-Wen SHI
Author Information
- Publication Type:Journal Article
- MeSH: Diterpenes; chemistry; isolation & purification; Heterocyclic Compounds, 4 or More Rings; Plant Stems; chemistry; Plants, Medicinal; chemistry; Taxoids; chemistry; isolation & purification; Taxus; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(18):1510-1513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents in the heartwood of Taxus cuspidata.
METHODSilica gel column chromatography, preparative HPLC and preparative TLC were used to isolate and purify the chemical constituents; 1H- and 13C-NMR spectroscopic methods were used for structural identification.
RESULTTen compounds, taxinine (1), taxusin (2), beta-sitosterol (3), 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl) butanoyloxy-4 (20), 11-taxadiene (5), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxyl-4 (20), 11-taxadiene (yunnanxane) (6), 9alpha, 10beta, 13alpha-triacetoxy-5alpha-cinnamoyltaxa-4 (20), 11-diene (7), 2-deacetoxytaxinine J (8), taxezopidine G (9), 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyl-taxa-4 (20), 11-dien-5-ol (5-decinnamoyltaxinine J) (10), were isolated and identified from the heartwood of T. cuspidata.
CONCLUSIONThree taxanes, 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxy)-4 (20), 11-taxadiene (yunnanxane) (6), and 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyltaxa-4 (20) , 11-dien-5-ol (10), were obtained from this plant for the first time.
