Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus.
- Author:
Shi-ping CHENG
1
;
Jia-lin LIU
;
Jing YUAN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Dose-Response Relationship, Drug; Endothelins; blood; Female; Glucocorticoids; administration & dosage; therapeutic use; Humans; Leeching; adverse effects; Lupus Erythematosus, Systemic; blood; therapy; Male; Middle Aged; Nausea; etiology; Prednisone; administration & dosage; therapeutic use; Receptors, Interleukin-2; blood; chemistry; Recurrence; Solubility
- From: Chinese journal of integrative medicine 2005;11(1):65-68
- CountryChina
- Language:English
-
Abstract:
OBJECTIVEto explore the mechanism of leeching in treating systemic lupus erythematosus (SLE).
METHODSForty-four patients with SLE were randomly divided into conventional corticosteroid treated group (control group, n = 20) and conventional treatment group with leeching intervention added (leeching group, n = 24). Before and after treatment the concentration of plasma endothelin (ET) and soluble interleukin-2 receptor (sIL-2R) were determined.
RESULTSBefore treatment the level of plasma ET and sIL-2R in the SLE patients were all higher than those in the normal healthy group, (P < 0.01). But after treatment the level of these in both groups were significantly improved than those of before treatment (P < 0.05), and comparison between these two treated groups showed that the difference between them was significant (P < 0.05).
CONCLUSIONLeeching added to conventional treatment of SLE could be more effective in improving the level of plasma ET and sIL-2R, and ameliorating the impairment of renal tissues.
