Pathology of AIDS-related lymphadenopathy and its relationship to expression of CD4 + CD25 + regulatory T cells in lymphoid node tissue.
- Author:
Zhen-wei LANG
1
;
Pei-qing MA
;
Hong-xin ZHAO
;
Meng-Dong LAN
;
Wen-bin DAO
;
Liang ZHANG
;
Bing SHEN
;
Xiao-hong SHI
;
Zhi-chun MA
;
Pei-zhi WANG
;
Fu-jie ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Acquired Immunodeficiency Syndrome; immunology; pathology; Adult; CD4 Lymphocyte Count; Female; Forkhead Transcription Factors; analysis; Humans; Immunohistochemistry; Lymph Nodes; immunology; pathology; Lymphatic Diseases; immunology; Male; Middle Aged; T-Lymphocytes, Regulatory; metabolism
- From: Acta Academiae Medicinae Sinicae 2006;28(5):622-625
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the pathology of AIDS-related lymphadenopathy and its relationship to the expression and distribution of CD4 + CD25 + regulatory T cells in lymphoid node tissue.
METHODSTotally 22 biopsy and 13 autopsy lymphoid node tissues from HIV-positive patients were examined under microscopy and pathological staging was performed. Specific marker for CD4 + CD25 + regulatory T cells in lymphoid node tissue was detected with anti-Foxp3 monoclonal antibody by immunohistochemistry.
RESULTSAmong all the 35 specimens, 5, 4, 14, and 12 specimens were histopathologically staged from 1 to 4, respectively. FoxP3 were detected in all lymphoid node tissues. The distribution of FoxP3-positive lymphocytes were mainly in intermediate zone of follicle and cortical area in stages 1 and 2. The counts of FoxP3-positive lymphocytes remarkably decreased in stages 3 and 4, following depletion of lymphocytes.
CONCLUSIONSCD4 + CD25 + regulatory T cells exist in lymphoid node tissue of patients with HIV infection. Their amounts decrease or deplete along with the progression of AIDS-related lymphadenopathy.
