Characteristics and Clinical Significance of CRLF2 Mutations in Adult Acute Lymphoblastic Leukemia.

Yan GU; Yu-Jie WU; Qi HAN; Xi-Lian ZHOU; Chun QIAO; Jian-Yong LI; Zheng GE

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Characteristics and Clinical Significance of CRLF2 Mutations in Adult Acute Lymphoblastic Leukemia.

VernacularTitle:成人急性淋巴细胞白血病CRLF2突变特点及其临床意义
Author: Yan GU ¹ ; Yu-Jie WU ¹ ; Qi HAN ¹ ; Xi-Lian ZHOU ¹ ; Chun QIAO ¹ ; Jian-Yong LI ¹ ; Zheng GE ² ;
Author Information

1. Department of Hematology, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
2. Department of Hematology, Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Publication Type:Journal Article
From: Journal of Experimental Hematology 2017;25(2):328-333
CountryChina
Language:Chinese
Abstract:
OBJECTIVECytokine receptor-like factor 2(CRLF2) plays an important role in the development of normal B lymphocytes, which can mediate early B cell proliferation and survival. The aim of this study was to investigate the mutations of CRLF2 and its clinical significance in adult patients with acute lymphoblastic leukemia(ALL).
METHODSExons of CRLF2 were amplified, then the DNA was purified and sequenced; the frequency, position, types and clinical significance of CRLF2 mutations were analyzed.
RESULTS6 types of genetic alterations in CRLF2 were found, among them the R186S prompted better prognosis, while L86I, F232F and W255C associated with poor prognosis.
CONCLUSIONCRLF2 mutations may play an important role in the development and progressions of adult patients with ALL, and these genetic abnormalities may associate with clinical outcome.