Circulating Neutrophil Counts Decrease in Response to Mitigated Air Quality in Stable COPD Patients.

Zi Li ZHANG; Jian WANG; Fen LIU; Ming Jing DING; Fei LIU; Si Fan CHEN; Wen Ju LU

Return

Circulating Neutrophil Counts Decrease in Response to Mitigated Air Quality in Stable COPD Patients.

Author: Zi Li ZHANG ¹ ; Jian WANG ² ; Fen LIU ³ ; Ming Jing DING ⁴ ; Fei LIU ¹ ; Si Fan CHEN ⁵ ; Wen Ju LU ² ;
Author Information

1. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
2. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China
3. The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
4. Department of Respiratory Medicine, Inner Mongolia Autonomous Region People's Hospital, Hohhot 010017, Inner Mongolia Autonomous Region, China.
5. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Publication Type:Journal Article
From: Biomedical and Environmental Sciences 2018;31(1):66-71
CountryChina
Language:English
Abstract: This three-year study, based on the Guangzhou Institute of Respiratory Disease (GRID), chronic obstructive pulmonary disease (COPD) Biobank, was conducted in 36 COPD patients to estimate whether changes in levels of leukocytes, erythrocytes, hemoglobin, and platelets were related to changes in air pollutant concentration. Daily NO2 levels exhibited significant differences between baseline years and the 2010 Asian Game period. We observed significant reductions in leukocyte and neutrophils counts levels, by 15.51% and 23.01%, from pre-Asian Games to during-Asian Games, respectively. In the post-Asian Game period, most pollutants approximated pre-Asian Game period levels, and similar effects were demonstrated in leukocyte and neutrophil counts. For both items, we identified significant increases resulting from elevated NO2 at lag days 0-2/5-6. We concluded that reductions in pollutants during the intervention period were associated with inactivation of hematological events in COPD.