Progress in metabolic engineering of β-carotene synthesis.

Author: Yanyan WANG ¹ ; Jianmin XING ² ; Hongge CHEN ¹
Author Information

1. College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, Henan, China.
2. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
Publication Type:Journal Article
Keywords: precursor; synthesis pathways; systems metabolic engineering; β-carotene
From: Chinese Journal of Biotechnology 2017;33(4):578-590
CountryChina
Language:Chinese
Abstract: β-carotene is an important natural plant pigment and has various physiological functions in organisms. With the proposition of systematic biology and progress in carotenoids biosynthesis since the 1960s, metabolic engineering has played a significant role in enhancing carotenoid production. In this review, we present β-carotene's traditional production methods and metabolic engineering strategies for constructing β-carotene-producing strains. Meanwhile, main problems and corresponding solutions to improve β-carotene yield of engineered strains were further analyzed, for further efficient microbial production of β-carotene.