Regulation of c-di-GMP metabolism and biofilm formation in Yersinia pestis.

Author: Juping ZHAO ¹ ; Yicheng SUN ¹
Author Information

1. Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Publication Type:Journal Article
Keywords: Yersinia pestis; biofilm; c-di-GMP; diguanylate cyclases; phosphodiesterase
From: Chinese Journal of Biotechnology 2017;33(9):1513-1524
CountryChina
Language:Chinese
Abstract: Yersinia pestis, the cause of plague, is transmitted by flea bite. Y. pestis forms a biofilm in the proventriculus of its flea vector to enhance transmission. Biofilm formation in Y. pestis is positively regulated by the intracellular levels of the second messenger cyclic diguanylate (c-di-GMP). The c-di-GMP in Y. pestis is synthesized by two diguanylate cyclases (DGC), HmsT and HmsD, and degraded by phosphodiesterase (PDE), HmsP. Here we summarized the regulators that modulate c-di-GMP metabolism and biofilm formation in Y. pestis and discussed their regulatory mechanism.