Retrospective analysis of maternal and infant birth features of hepatoblastoma patients.
- Author:
Cong-lun PU
1
;
Chun-bao GUO
;
Xian-qing JIN
;
Chun DENG
;
Ming-man ZHANG
;
Ying-cun LI
;
Quan KANG
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Child; Child, Preschool; Confidence Intervals; Female; Follow-Up Studies; Hepatoblastoma; epidemiology; etiology; prevention & control; Humans; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Liver Neoplasms; epidemiology; etiology; prevention & control; Male; Overweight; Pregnancy; Retrospective Studies; Risk Factors; Smoking; adverse effects
- From: Chinese Journal of Hepatology 2009;17(6):459-461
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the risk factors for hepatoblastoma.
METHODSA case-cohort study using Logistic regression multiple variables analysis of medical record data sets was conducted to examine infant and perinatal risk factors for hepatoblastoma.
RESULTSBirth weight less than 1,000 g was associated with a strongly increased risk of hepatoblastoma (odds risk, OR = 26.0, 95% confidence interval, CI: 14.0 to 65.7). After adjustment of birth weight, a moderately increased risk of hepatoblastoma was found for older maternal age ( > 35 years vs. 20 to 34 years: OR = 2.6, 95% CI: 0.9 to 5.9), maternal smoking (OR = 2.9, 95% CI: 1.1 to 4.2) and higher maternal pregnancy body mass index (OR = 3.2, 95% CI: 1.0 to 6.7).
CONCLUSIONVery low birth weight and maternal characteristics including overweight, smoking are associated with hepatoblastoma risk.
