Significance of soluble DLL1 in diagnosis of intracranial infectious diseases in children.
- Author:
Jin-Yi LI
1
;
Yan-Jie JIA
;
Yong-Lin JIA
;
Jing-Jing LU
;
Li-Jun JING
;
Tao PENG
;
Jing-Hong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Female; Humans; Intercellular Signaling Peptides and Proteins; analysis; blood; cerebrospinal fluid; Male; Membrane Proteins; analysis; blood; cerebrospinal fluid; Meningitis, Bacterial; diagnosis; Meningitis, Viral; diagnosis; Suppuration; diagnosis; Tuberculosis, Meningeal; diagnosis
- From: Chinese Journal of Contemporary Pediatrics 2011;13(3):205-207
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the significance of soluble DLL1 (Delta-like-1) levels of cerebrospinal fluid (CSF) and serum in the diagnosis of intracranial infection in children.
METHODSFifty children with intracranial infection, including 20 cases of tuberculous meningitis (TM), 20 cases of viral meningitis (VM) and 10 cases of purulent meningitis (PM), and 20 children without intracranial infection (control group) were enrolled. The levels of soluble DLL1 in CSF and serum were measured using ELISA.
RESULTSThe level of CSF soluble DLL1 in the TM group was significantly higher than that in the VM, PM and control groups (2.89 ± 1.72 ng/mL vs 0.14 ± 0.14 ng/mL, 0.27 ± 0.21 ng/mL, 0.13 ± 0.12 ng/mL; P<0.01). The level of serum soluble DLL1 in the TM group was also significantly higher than that in the VM, PM and control groups (12.61 ± 6.45 ng/mL vs 2.28 ± 2.27 ng/mL, 2.38 ± 1.79 ng/mL, 2.26 ± 2.10 ng/mL; P<0.01). The levels of soluble DLL1 in the CSF and serum in the VM and PM groups were not significantly different from those in the control group.
CONCLUSIONSSoluble DLL1 as a novel indicator might have potentially important value in the diagnosis of TM.
