Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura.
- Author:
Xue-Ping WANG
1
;
Yun-Shu QIU
;
Guo-Ping HAO
;
Lei ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; CD3 Complex; analysis; CD4 Antigens; analysis; Child; Child, Preschool; Female; Flow Cytometry; Humans; Infant; Interleukin-2 Receptor alpha Subunit; analysis; Interleukin-7 Receptor alpha Subunit; analysis; Male; Purpura, Thrombocytopenic, Idiopathic; etiology; immunology; T-Lymphocytes, Regulatory; immunology
- From: Chinese Journal of Contemporary Pediatrics 2011;13(4):282-284
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the levels of CD4+CD25+CD127- and CD3+CD4-CD8- regulatory T (Treg) cells in peripheral blood of children with idiopathic thrombocytopenic purpura (ITP).
METHODSThe flow cytometry was used to detect the expression of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells in peripheral blood of 33 children with ITP and 21 healthy children.
RESULTSThe expression levels of CD4+CD25+CD127-［(2.7±1.7)% vs (4.8±1.6)%; P<0.01］and CD3+CD4-CD8-［(5.2±3.1)% vs (8.1±3.5)%; P<0.01］Treg cells in children with ITP were significantly lower than in the controls.
CONCLUSIONSThe expression levels of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells decrease in children with ITP, suggesting that CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells might play a role in the pathogenesis of ITP.
