Association of genetic polymorphism in plasminogen activator inhibitor-1 gene with endometrial hypoplasia in infertile women.
- Author:
Jing-hua SUN
1
;
Li -xue GUAN
;
Dong-ju LIN
;
Pei-feng DAI
;
Li PAN
;
Qian MU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Humans; Infertility; genetics; Plasminogen Activator Inhibitor 1; genetics; Polymorphism, Genetic; Pregnancy; Uterine Diseases; genetics; Women's Health
- From: Chinese Journal of Medical Genetics 2008;25(4):462-464
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the plasminogen activator inhibitor (PAI-1) polymorphisms and endometrial hypoplasia in infertile women.
METHODSThe study was conducted in 105 primary infertile patients with endometrial hypoplasia diagnosed by pathology and the thickness of endometrium by B-mode ultrasound and 85 controls who were not pregnant and had normal fertility. The -675 4G/5G polymorphism in the PAI-1 gene was detected by polymerase chain reaction-restriction fragment length polymerphim analysis.
RESULTSThe frequencies of 4G/4G genotype and 4G allele of the PAI-1 gene were higher in the patient group (48.6% and 66.2%) than in the normal controls (22.4% and 47.1%) (P < 0.01). ThePAI-1 4G/4G genotype was significantly associated with endometrial hypoplasia in the infertile patients (OR=4.9, 95% CI: 2.10-10.12).
CONCLUSIONThe present findings suggest that the 4G/5G polymorphism of the PAI-1 gene was associated with endometrial hypoplasia in infertile patients.
