The association of genetic polymorphism of dendritic cell-specific ICAM-grabbing nonintegrin and hepatitis C infection.
- Author:
Min WANG
1
;
Hong-xing HAN
;
Jian LU
;
Sai-yu LIU
;
Qiang JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alleles; Cell Adhesion Molecules; genetics; Child; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Hepacivirus; genetics; Hepatitis C, Chronic; ethnology; genetics; virology; Humans; Lectins, C-Type; genetics; Male; Middle Aged; Polymerase Chain Reaction; methods; Polymorphism, Genetic; RNA, Viral; Receptors, Cell Surface; genetics; Viral Load; Young Adult
- From: Chinese Journal of Hepatology 2009;17(9):645-648
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of genetic polymorphism of dendritic cell-specific ICAM-grabbing nonintegrin (DC-SIGNR) and hepatitis C infection.
METHODSPatients with hepatitis C (n = 268) were genotyped and analysed for the repeat sequences polymorphism of DC-SIGNR using PCR and DNA sequencing. HCV virus load and HCV RNA genotypes were analyzed. Inter-group comparison was analyzed using LSD method.
RESULTSNo significant correlation was found between DC-SIGNR genotypes/ alleles and HCV RNA genotypes in patients. HCV-infected patients with 7-repeat (medium) alleles had lower HCV RNA levels compared to patients with 9-repeat (onger) alleles (P = 0.036). HCV-infected patients with 7/7 genotype had lower HCV RNA levels compared to patients with 9/7 genotype (P = 0.025). These findings suggest that optimal attachment of hepatitis C virions to DC-SIGNR may be associated with longer alleles.
CONCLUSIONThe fact that DC-SIGNR polymorphism might affect HCV loads supports the concept that DC-SIGNR contributes to HCV replication efficacy. There is no significant correlation between the genetic polymorphism of DC-SIGNR and HCV-RNA genotypes.
