Etiology of aseptic meningitis prevalent in Xuzhou.
- Author:
Xian LI
1
;
Xi-ling GUO
;
Zhi-yang SHI
;
Da-xin NI
;
Hua WANG
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Viral; immunology; Child; Child, Preschool; China; epidemiology; Coxsackievirus Infections; cerebrospinal fluid; epidemiology; virology; Echovirus Infections; cerebrospinal fluid; epidemiology; virology; Enterovirus; genetics; immunology; isolation & purification; Humans; Infant; Meningitis, Aseptic; cerebrospinal fluid; epidemiology; virology; Microscopy, Electron; Neutralization Tests; Prevalence; RNA, Viral; genetics; Reverse Transcriptase Polymerase Chain Reaction; Virion; isolation & purification; ultrastructure
- From: Chinese Journal of Experimental and Clinical Virology 2006;20(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo find the pathogenic agents of aseptic meningitis prevalent in Xuzhou of Jiangsu province in 2001.
METHODSThe enterovirus (EV) was cultured from CSF of the patients and identified with anti-serum by neutralization test. Neutralization titer of antibody in paired sera from meningitis children was determined. EV RNA was detected by RT-PCR.
RESULTSFour strains of Coxsackievirus B5, 2 strains of Coxsackievirus B3 and 1 strain of Echovirus 7 were isolated from 22 CSF specimens. The isolation rate of virus was 31.8% (7/22), 21 CSF were tested by RT-PCR, the positive rate of EV RNA was 52.4% (11/21); 57.9% (11/19) of patients paired-sera had over 4 folds antibody rise or became seroconverted.
CONCLUSIONEnterovirus was the pathogenic agent of aseptic meningitis prevalent in Xuzhou of Jiangsu province, the main serotype of the virus was Coxsackievirus B5.
