A clinical study on combined serum hepatic fibrosis-related markers and ultrasound parameters to diagnose hepatic fibrosis.
- Author:
Jing YU
1
;
Chang-he JIA
;
Qi WANG
;
Po-shi XU
;
Hao ZHANG
;
Yu-qin ZHAO
;
Quan SHEN
;
Yan-rui HAO
;
Gui-fen CAI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alanine Transaminase; blood; Biomarkers; blood; Collagen Type III; blood; Female; Hepatitis B, Chronic; blood; diagnosis; diagnostic imaging; Humans; Hyaluronic Acid; blood; Liver Cirrhosis; blood; diagnosis; diagnostic imaging; Male; Middle Aged; Platelet-Derived Growth Factor; analysis; Proto-Oncogene Proteins c-sis; Reproducibility of Results; Sensitivity and Specificity; Tissue Inhibitor of Metalloproteinase-1; blood; Transforming Growth Factor beta; blood; Ultrasonography, Doppler, Color; methods; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(1):56-58
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study attempted to explore the value of combining serum hepatic fibrosis-related markers and ultrasound parameters together on diagnosis of hepatic fibrosis.
METHODSSix serum markers and 8 ultrasound parameters were measured from 100 patients with chronic hepatitis B or cirrhosis. The results of the serum hepatic fibrosis-related markers and ultrasound in disease group were analyzed and compared with the findings of hepatic pathology.
RESULTSBy filtrating,the group of platelet derived growth factor-BB (PDGF-BB) plus hyaluronic acid (HA) plus echo characteristics of liver parenchyma (LPEC) plus length of spleen (SL) had the highest Se and Spe, which were 90.7% and 85.4% respectively.
CONCLUSIONThe advantageous combination of serum markers and ultrasound parameters can significantly improve Se and Spe, which is superior to any single serum index or ultrasound parameter. And it was a better non-invasive method for diagnosing hepatic fibrosis.
