Chemical constituents from Solanum coagulans.
- Author:
Wen-na ZHANG
- Publication Type:Journal Article
- MeSH:
Cell Line, Tumor;
Flavonols;
chemistry;
isolation & purification;
pharmacology;
Humans;
Saponins;
chemistry;
isolation & purification;
pharmacology;
Solanum;
chemistry
- From:
China Journal of Chinese Materia Medica
2015;40(2):264-268
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds, including five steroidal saponins and five flavonol glycosides, were isolated from the whole plant of Solanum coagulans by means of column chromatographies over silica gel, ODS, Sephadex LH-20, and preparative HPLC. Based on analysis of MS and NMR spectroscopic data, their structures were established as anguiviosides XV (1), smilaxchinoside A (2), methylprotodioscin (3), protodioscin (4), solamargine (5), 3', 4', 5-trihydroxy-7-methoxy-6-C-β-D-glucopyranoside (6), brainoside B (7), camsibriside A (8), kampferol 3-O-(2"-β-D-galactopyranosyl)-β-D-glucopyranoside (9), and quercetin-3-O-(2"-β-D-galactopyranosyl)-β-D-glucopyranoside (10). All the compounds were first isolated from this plant. In the in vitro assays, compounds 4 and 5 showed cytotoxic activity against SMCC-7721 and NCI-H460.
