Immune activity of heat shock protein gp96 and its application in active immunotherapy for tumor and infectious diseases.
- Author:
Yaxing XU
1
;
Saifeng WANG
;
Xiaojun ZHANG
;
Songdong MENG
Author Information
1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Communicable Diseases;
therapy;
Heat-Shock Proteins;
immunology;
therapeutic use;
Humans;
Immunotherapy, Active;
methods;
Neoplasms;
therapy;
T-Lymphocytes, Regulatory;
immunology
- From:
Chinese Journal of Biotechnology
2012;28(3):261-266
- CountryChina
- Language:Chinese
-
Abstract:
Heat-shock protein gp96 associates with antigenic peptides derived from tumor and virus. Exogenous gp96-peptide complexes are taken up by antigen-presenting cells through interaction with its receptor CD91 on the cell surface, and cross-present antigenic peptides to MHC class I molecules by a peptide relay line in the endoplasmic reticulum for specific T-cell activation. Meanwhile, gp96 has been shown to initiate innate immune responses through interaction with toll-like receptor 2 and toll-like receptor 4. Recent studies have shown a gp96-mediated immune balance between CTL and Tregs. With the further understanding of counteracting immunosuppressive mechanisms in gp96-induced cellular immune responses, and establishment of high level production of recombinant gp96 by the yeast, gp96 appears to be a promising candidate for designing effective therapeutic vaccines against tumor and infectious diseases.
