Factors associated with the efficacy of cardiac resynchronization therapy in patients with chronic heart failure
10.3760/cma.j.issn.0253-3758.2014.09.005
- VernacularTitle:影响慢性心力衰竭患者心脏再同步化治疗效果的因素分析
- Author:
Ying ZHOU
1
;
Minfang BAO
;
Haiyan LIN
;
Shangwei HUANG
;
Yifei XU
;
Geng XU
Author Information
1. 浙江大学医学院附属第二医院心血管内科
- Keywords:
Heart failure,congestive;
Treatment outcome;
Cardiac resynchronization therapy
- From:
Chinese Journal of Cardiology
2014;42(9):731-735
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of cardiac resynchronization therapy (CRT)in patients with chronic heart failure,and compare the clinical characteristics and outcome between responders and non-responders to define factors related to the efficacy of CRT.Methods We retrospectively analyzed the data of patients underwent CRT-P/D implantation from January 2006 to December 2012 in our Hospital.All patients received long-term follow-up including NYHA classification,left ventricular ejection fraction (LVEF) and left ventricular internal dimension at end diastole (LVIDd).Results A total of 204 patients were included (130 males,mean age (64.8 ± 11.9) years).The total response rate of CRT was 61.3％.Women,QRS duration ≥150 ms,and left bundle branch block (LBBB) were related with better response after CRT (all P ＜ 0.05).Multivariate regression analysis showed that QRS duration was an independent determinant for CRT response.All-cause mortality rate was significantly lower in responder group than in non-responder group (P ＜ 0.001).Conclusions In patients with chronic heart failure,women,QRS duration ≥ 150 ms,and LBBB are related with better CRT response rate post CRT.QRS duration ≥ 150 ms is an independent predictor of CRT response,and positive response is associated with lower all-cause mortality in this oatient cohort.
