Roles of Wnt-1, beta-catenin and adenomatous polyposis coli in the differentiation and proliferation of oral squamous cell carcinoma.
- Author:
Wei-min ZHANG
1
;
Yan GAO
Author Information
- Publication Type:Journal Article
- MeSH: Adenomatous Polyposis Coli Protein; metabolism; Carcinoma, Squamous Cell; metabolism; pathology; Cell Differentiation; Cell Proliferation; Humans; Mouth Neoplasms; metabolism; pathology; Signal Transduction; Wnt1 Protein; metabolism; beta Catenin; metabolism
- From: Chinese Journal of Stomatology 2005;40(6):491-494
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of Wnt-1, beta-catenin and adenomatous polyposis coli (APC) in oral squamous cell carcinoma (OSCC).
METHODSSurgical specimens from 66 OSCC patients were examined for Wnt-1, beta-catenin, APC and MIB-1 expressions by immunohistochemical staining.
RESULTSAmong all the 37 cases of well differentiated OSCCs, there were 30, 25 and 31 cases of high expressions of Wnt-1, APC and beta-catenin, respectively, 7, 12 and 6 cases of low expressions. Among all the 29 cases of moderate and poor differentiated OSCCs, there were 6, 9 and 11 cases of high expressions of Wnt-1, APC and beta-catenin respectively, 23, 20 and 18 cases of low expressions. Among all the 66 cases of OSCCs, there were 32 cases of high expressions of MIB-1 and 34 cases of low expressions. Expressions of Wnt-1, beta-catenin and APC showed significant difference in different differentiation of OSCC.
CONCLUSIONSWnt-1, beta-catenin and APC expressions were related to the differentiation of OSCC.
