Application of 18F-fluorodeoxyglucose positron emission tomography in diagnosis of malignant diseases.
- Author:
Xiao-hong NING
1
;
Qiu-li MENG
;
Yu-zhou WANG
;
Chun-mei BAI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; diagnosis; pathology; Neoplasms, Unknown Primary; diagnosis; pathology; Positron-Emission Tomography; methods; Radiopharmaceuticals; metabolism; Retrospective Studies; Sensitivity and Specificity; Young Adult
- From: Chinese Medical Sciences Journal 2009;24(2):117-121
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo testify the efficacy of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in the diagnosis of cancer.
METHODSA total of 170 patients with diagnosed cancer or suspicious cancer were enrolled in this study, and underwent 18F-FDG PET. The standard uptake value (SUV) and diameter for each abnormal region in PET images were analyzed. All data were analyzed by SPSS 11.5.
RESULTSPET scan identified a primary cancer in 45.8% (11/24) patients. The sensitivity and specificity of PET scan in differentiating malignant lesions from benign ones were 78.8% (52/66) and 77.1% (27/35) respectively. Twenty-nine out of 68 (42.6%) lesions were detected earlier by PET than by computed tomography. The SUV of primary cancer was significantly higher than that of metastatic lymph nodes (5.84 +/- 3.12 vs. 3.14 +/- 2.24, P<0.001). And SUV of primary lung cancer was also significantly higher than that of metastatic lung cancer (6.30 +/- 3.01 vs. 2.86 +/- 2.37, P<0.01).
CONCLUSION18F-FDG PET plays a very important role in cancer diagnosis.
