Effect of umbilical cord MSC infusion on the pulmonary infection in haploidentical hematopoietic stem cell transplantation.
10.7534/j.issn.1009-2137.2014.04.037
- Author:
Dong-Mei HAN
1
;
Zhi-Dong WANG
1
;
Li DING
1
;
Xiao-Li ZHENG
1
;
Hong-Min YAN
1
;
Mei XUE
1
;
Ling ZHU
1
;
Jing LIU
1
;
Heng-Xiang WANG
2
Author Information
1. Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
2. Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China. E-mail: wanghengxiang123@yahoo.com.cn.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Child;
Child, Preschool;
Cytomegalovirus Infections;
epidemiology;
Female;
Hematopoietic Stem Cell Transplantation;
methods;
Humans;
Lung Diseases;
epidemiology;
Male;
Mesenchymal Stromal Cells;
cytology;
Transplantation Conditioning;
Transplantation, Homologous;
Treatment Outcome;
Umbilical Cord;
cytology;
Young Adult
- From:
Journal of Experimental Hematology
2014;22(4):1084-1088
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the effect of umbilical cord mesenchymal cells (UC-MSC) infusion on the pulmonary infection in haploidentical hematopoietic stem cell transplantation (hi-HSCT). The infection of 83 patients underwent hi-HSCT was detected and analysed, among them 42 patients received haploidentical hi-HSCT, 41 received hi-HSCT combined with UC-MSC infusion. The results showed that 31 cases (73.81% ± 6.78%) were infected by cytomegalovirus and 21 cases in patients received hi-HSCT experienced pulmonary infections, including infections of fungal, virus, bacteria, tubercle bacillus, PCP and so on, the incidence rate was (50 ± 7.72)%; the infection of cytomegalovirus (CMV) was found in 31 cases, the incidence rate was (78.05 ± 6.46)%. In patients received hi-HSCT combined with UC-MSC, only 15 patients experienced pulmonary infection, the incidence rate was (36.59 ± 7.52)%, and the infection of cytomegalovirus (CMV) was observed in 32 patients, the incidence rate was (78.05 ± 6.46)%. There was no obvious statistical difference between two groups(P > 0.05). It is concluded that the UC-MSC infusion not increases the infection rate in hi-HSCT.
