Effects of kappa-opioid receptor stimulation on high glucose induced myocardial hypertrophy of neonatal rats.
- Author:
Dong-Mei LIU
1
;
Hong-Xin WANG
;
Lei ZHANG
;
Mei-Li LU
;
Guo-Qiang WU
Author Information
- Publication Type:Journal Article
- MeSH: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; pharmacology; Animals; Animals, Newborn; Cardiomegaly; metabolism; Cells, Cultured; Female; Glucose; adverse effects; MAP Kinase Signaling System; Male; Myocytes, Cardiac; drug effects; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; metabolism
- From: Chinese Journal of Applied Physiology 2010;26(4):463-465
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of kappa-opioid receptor stimulation on high glucose induced myocardial hypertrophy of neonatal rats.
METHODSUsing cultured myocardial cells as a model, the protein content was assayed with Lowrys method. The cardiomyocytes volumes were measured by computer photograph analysis system. The level of p-ERK44/42 was determined by Western blot.
RESULTSCompared with the control, U50488H significantly inhibited the protein content and volumes of cultured hypertrophic myocardial cells induced by high glucose. Meanwhile the role of ERK was important.
CONCLUSIONThe stimulation of kappa-opioid can inhibit myocardial hypertrophy induced by high glucose, which is possibly via attenuating p-ERK.
