Effect of celecoxib on pulmonary hypertension of chronic hypoxia and hypercapnic rats.
- Author:
Hai-Huan ZENG
1
,
2
;
Ling-Jie LIU
;
Yu-Ping HUANG
;
Yu-Peng XIE
;
Liang-Xing WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Celecoxib; Chronic Disease; Cyclooxygenase 2 Inhibitors; adverse effects; pharmacology; Epoprostenol; blood; Hypercapnia; complications; Hypertension, Pulmonary; etiology; physiopathology; Hypoxia; complications; Male; Pyrazoles; adverse effects; pharmacology; Rats; Rats, Sprague-Dawley; Sulfonamides; adverse effects; pharmacology; Thromboxane A2; blood
- From: Chinese Journal of Applied Physiology 2011;27(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of celecoxib on chronic hypoxia and hypercapnic pulmonary hypertension.
METHODSSD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia+ celecoxib group (C). The content of TXB2 and 6-keto-PGF1alpha in plasma and lung were detected by the technique of radioimmunology.
RESULTS(1) Mean pulmonary arteria pressure(mPAP) was significantly higher in rats of B group than those of A group. mPAP was significantly higher in rats of C group than those of B group. Differences of mPAP were not significant in three groups. (2) The content of TXB2 in plasma and lung and the ratio of TXB2/6-keto-PGF1alpha were significantly higher in rats of B group than those of A group. The ratio of TXB2/6-keto-PGF1alpha was significantly higher and the content of 6-keto-PGF1alpha in plasma and lung was significantly lower in rats of C group than those of B group. (3) Light microscopy showed that WA/TA (vessel wall area/total area) and PAMT (the thickness of medial smooth cell layer) were significantly higher in rats of B group than those of A group. WA/TA and PAMT were significantly higher in rats of C group than those of B group. (4) Electron microscopy showed the thickening of vessel wall and the proliferation of collagen fiber in B group and augmentation of smooth muscle cell and abundance of myofilament in pulmonary arterioles in C group.
CONCLUSIONCelecoxib can aggravate hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling by increasing the ratio of TXA2/PGI2.
