Preparation, identification and thermodynamic stability of capsaicin-hydroxypropyl-beta-cyclodextrin inclusion compound.
- Author:
Xiaoyu CHEN
1
;
Zhirong ZHANG
;
Ke REN
;
Tao GONG
Author Information
- Publication Type:Journal Article
- MeSH: 2-Hydroxypropyl-beta-cyclodextrin; Calorimetry, Differential Scanning; Capsaicin; chemistry; Drug Compounding; Drug Stability; Solubility; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; methods; Thermodynamics; X-Ray Diffraction; X-Rays; beta-Cyclodextrins; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(4):394-397
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare and identify the capsaicin-hydroxypropyl-beta-cyclodextrin (capsaicin-HP-beta-CD) inclusion compound the mol ratio between capsaicin and HP-beta-CD and the thermodynamic constants in inclusion were studied simultaneously.
METHODThe capsaicin-HP-beta-CD inclusion compound was prepared with the method of saturation aqueous solution. Meanwhile, the inclusion compound was identified by differential scanning calorimetry methods (DSC), infrared spectrometry (IR), and X-ray diffraction (XRD), respectively. The mol ratio between host and guest molecular and the thermodynamic constants during the inclusion process were also researched by phase solubility method.
RESULTAn 1 : 1 molar ratio inclusion compound of capsaicin with HP-beta-CD could form at 25, 35 and 45 degrees C. The phase diagram was A(L) type.
CONCLUSIONThe solubility of capsaicin-HP-beta-CD inclusion compound can be increased obviously.
