Association between IL-6 C-572G and susceptibility to spontaneous preterm birth.
- Author:
Xiao YANG
1
;
Wei PENG
;
Li-Na ZHU
;
Xiao-Ai ZHANG
;
Yan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Infant, Newborn; Interleukin-6; genetics; Polymorphism, Single Nucleotide; Pregnancy; Premature Birth; genetics
- From: Chinese Journal of Contemporary Pediatrics 2017;19(7):806-811
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the genetic polymorphism of IL-6 C-572G and susceptibility to spontaneous preterm birth (SPTB).
METHODSThe subjects were from Beijing and the surrounding areas of Beijing. This case-control study enrolled 569 SPTB infants, including 56 extremely preterm (<28 weeks of gestation), 166 very preterm (28-31weeks of gestation) and 347 moderate to late preterm infants (32 to 36weeks of gestation). A total of 673 term infants were enrolled as the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphism of IL-6 C-572G.
RESULTSCompared with the CC genotypes, the IL-6 C-572G G-positive genotype (CG+GG genotype) was significantly associated with an increased susceptibility to moderate to late SPTB (OR=1.35, 95%CI: 1.01-1.80, P=0.04).
CONCLUSIONSAmong the Chinese population, IL-6 C-572G polymorphism is associated with susceptibility to moderate to late SPTB.
