Development of Targets for Anti-influenza Virus Based on Nucleoprotein.
- Author:
Zhisheng HUANG
;
Jian SUN
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Discovery;
methods;
Humans;
Influenza A virus;
drug effects;
metabolism;
physiology;
Influenza, Human;
drug therapy;
Molecular Targeted Therapy;
methods;
Nucleoproteins;
chemistry;
metabolism;
Virus Replication;
drug effects
- From:
Chinese Journal of Virology
2015;31(4):450-456
- CountryChina
- Language:Chinese
-
Abstract:
The influenza A is an acute respiratory infection persistently threatening human health and social stability, and has caused high morbidity and mortality. The development of novel anti-influenza drugs based on new targets is very significant because of high mutation and drug resistance of influenza virus. The nucleoprotein of influenza A virus identified high conservation, provides cross immune protection as a potential target of anti-influenza drugs and reports on relevant studies have been published at home and a- board. Herbal drug as a traditional Chinese medicine shows the distinct advantages in the aspect of prevention and treatment of influenza A. This paper analyzes the structure and function of influenza a virus, and reviews the advances in the research on anti-influenza targets based on the nucleoprotein of the influenza A virus.
