Molecular Mechanism of Glycoprotein-induced Cell-Cell Fusion of Herpesviruses.
- Author:
Daishen FENG
;
Renyong JIA
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Fusion;
Glycoproteins;
genetics;
metabolism;
Herpesviridae;
genetics;
metabolism;
Herpesviridae Infections;
physiopathology;
virology;
Humans;
Viral Proteins;
genetics;
metabolism
- From:
Chinese Journal of Virology
2016;32(1):101-107
- CountryChina
- Language:Chinese
-
Abstract:
Herpesviridae is a large family comprising linear, double-stranded DNA viruses. Herpesviridae contains three subfamilies: α-, β- and γ-herpesviruses. The glycoproteins gB, gH and gL of each subfamily form the "core fusion function" in cell-cell fusion. Other herpesviruses also need additional glycoproteins to promote fusion, such as gD of the Herpes simplex virus, gp42 of the Epstein-Barr virus, and gO or UL128-131 of the Human cytomegalovirus. In contrast, glycoproteins gM or gM/gN of herpesvirus inhibit fusion. We describe the molecular mechanisms of glycoprotein-induced fusion and entry of herpesviruses. It will be helpful to further study the pathogenic mechanism of herpesvirus.
