HTLV-1 bZIP Factor (HBZ): Roles in HTLV-1 Oncogenesis.
- Author:
Wencai WU
;
Wenzhao CHENG
;
Mengyun CHEN
;
Lingling XU
;
Tiejun ZHAO
- Publication Type:Journal Article
- MeSH:
Animals;
Basic-Leucine Zipper Transcription Factors;
genetics;
metabolism;
Carcinogenesis;
HTLV-I Infections;
pathology;
virology;
Human T-lymphotropic virus 1;
genetics;
metabolism;
Humans;
Leukemia, T-Cell;
pathology;
virology;
Retroviridae Proteins;
genetics;
metabolism
- From:
Chinese Journal of Virology
2016;32(2):235-242
- CountryChina
- Language:Chinese
-
Abstract:
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus demonstrated to be associated with human disease. Infection by the HTLV-1 can cause T-cell leukemia (ATL) in adults. HTLV-1 bZIP factor (HBZ) is a viral protein encoded by the minus strand of the HTLV-1 provirus. Among the regulatory and accessory genes of HTLV-1, HBZ is the only gene that remains intact and which is expressed consistently in all patients with ATL. Moreover, HBZ has a critical role in the leukemogenesis of ATL. Here, we review the function of HBZ in the oncogenesis of HTLV-1 and its molecular mechanism of action.
