Rosuvastatin attenuates vascular endothelial adhesiveness in apolipoprotein E-deficient mice
10.3760/cma.j.issn.0253-3758.2009.01.015
- VernacularTitle:瑞舒伐他汀对载脂蛋白E基因敲除小鼠血管内皮黏附性的影响
- Author:
Wei LI
1
;
Hai-Ring HUANG
;
Zhi-Yong WU
;
Fang-Qiu XIE
;
Xu-Ri ZHANG
;
Pin GUAN
Author Information
1. 海南省人民医院
- Keywords:
Antilipemic agents;
Apolipoproteins E;
Mice,knockout
- From:
Chinese Journal of Cardiology
2009;37(1):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-inflammatory effects on the vessel wall of rosuvastatin chow diet were treated with vehicle or various doses of rosuvagtatin(1,5,or 20 ms/kg)by subcutaneous injection for 2 or 6 weeks prior to sacrifice.Endothelial adhesiveness for monocytcs was determined by functional binding assay.The expressions of vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 in the vessel wall were detected by quantitative real-time polymerase chain reaction.Results Endothelial adhesiveness for monocytes was significantly attenuated after 2 or 6 weeks treatments with 5 or 20 mg/kg rosuvaatatin.Rosuvastatin also significantly reduced the expressions of vescular cell adhesion moIecule-1 and monocyte chemotactie protein-1 in the vessel wall Conclusion The anti-inflammatory effects of suvagtatin might be responsible for attenuating the pathogenesis of atherogenesis in apolipoprotein E-deficient mice.
