The prevention of canine osteoradionecrosis of jaws by low-intensity ultrasound
10.3760/cma.j.issn.1002-0098.2015.05.009
- VernacularTitle:低强度超声预防颌骨放射性骨坏死的实验研究
- Author:
Zhihui ZHOU
1
;
Weiwei FAN
;
Miaojie LANG
;
Yanliang WANG
Author Information
1. 温州医科大学口腔医学院·附属口腔医院口腔颌面外科
- Keywords:
Osteoradionecrosis;
Mandible;
Ultrasonic therapy
- From:
Chinese Journal of Stomatology
2015;50(5):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effect of low-intensity ultrasound on osteoradionecrosis of jaws (ORNJ).Methods Twenty-five canines were randomly divided into experimental group (n=20)and control group (n=5).The canines in experimental group received radiation exposure,and then were randomly subdivided into group A (n=10)and group B (n=10).Control group did not undergo radiotherapy.One month after radiotherapy,the fourth mandibular premolars of all animals were extracted.Group B was immediately treated by low-intensity ultrasound for twenty days,group A and control group did not receive any treatment.Two months after tooth extraction,the formation of ORNJ was determined and the occurrence rate of ORNJ was compared between group A and B.The microstructure of the mandible and changes in microvascular density in group A and B were evaluated and compared with those of control group.Results All animals in group B and group A developed ORNJ after prophylactic ultrasound was applied for twenty days.Although the imaging examination of bony density of group A and B were lower than normal animals in control group,bone density in group B was significantly better than group A.Micro-CT showed that the trabecular bone volume fraction,trabecular thickness,bone surface/bone volume and trabecular number in group B were respectively (0.187±0.029)％,(0.160±0.039) μm,(12.536±2.558)/mm,(1.227± 0.192)/mm,which were all greater than group A [(0.103±0.014)％,(0.069±0.013) μm,(5.598±0.731)/mm,(0.522 ± 0.064)/mm)] (P＜0.05).Conclusions Although the preventive application of low intensity ultrasound can not prevent the formation of ORNJ,but can significantly improve the symptoms of ORNJ.
