The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells.
- Author:
Joon-Ho KEUM
1
;
Ok-Hwa KANG
;
Sung-Bae KIM
;
Su-Hyun MUN
;
Yun-Soo SEO
;
Ma-Ryong KIM
;
Jung-Rae RHO
;
Young-Seob LEE
;
Chung-Berm PARK
;
Young-Guk KIM
;
Yong-Il KIM
;
Sin-Hee HAN
;
Dong-Yeul KWON
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents; pharmacology; therapeutic use; Bone Marrow Cells; pathology; Calcimycin; pharmacology; Cell Degranulation; drug effects; Cell Survival; drug effects; Drugs, Chinese Herbal; pharmacology; therapeutic use; Hypersensitivity; drug therapy; pathology; Interleukin-6; secretion; Leukotriene C4; pharmacology; Male; Mast Cells; drug effects; pathology; physiology; Mice; Mice, Inbred BALB C; Prostaglandin D2; biosynthesis; Tetradecanoylphorbol Acetate; pharmacology; beta-N-Acetylhexosaminidases; metabolism
- From: Chinese journal of integrative medicine 2013;19(5):380-386
- CountryChina
- Language:English
-
Abstract:
OBJECTIVECheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction () and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms.
METHODSIn this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included interleukin-6 (IL-6), prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and β-hexosaminidase (β-hex).
RESULTSOur data revealed that CITE inhibited the production of IL-6, PGD2, LTC4, and β-hex induced by PMA plus A23187 (P<0.05).
CONCLUSIONThese findings indicate that CITE has the potential for use in the treatment of allergy.
