Real-world study of effect on liver function of parenterally administered shuxuetong with different doses.
- Author:
Zhi-Fei WANG
1
,
2
;
Jian HUO
3
;
Jun-Jie JIANG
4
;
Yan-Ming XIE
4
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alanine Transaminase; metabolism; Aspartate Aminotransferases; metabolism; Case-Control Studies; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; administration & dosage; adverse effects; Female; Hospital Information Systems; statistics & numerical data; Humans; Infusions, Parenteral; Liver; drug effects; enzymology; physiopathology; Male; Middle Aged; Pragmatic Clinical Trials as Topic; Propensity Score; Retrospective Studies; Young Adult
- From: China Journal of Chinese Materia Medica 2013;38(18):3068-3075
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the effect on liver function of parenterally administered Shuxuetong Injection with different doses.
METHODThe study is based on hospital information system (HIS) data. We group the cases by dose: The observation group receive a dose > 6 mL (recommended daily dose), the matched group receive the recommended dose. Chi-square test, logistic regression, logistic regression with propensity score, logistic regression with GBM propensity score were used to find the between group differences in ALT and AST after using parentyerally administered Shuxuetong injection.
RESULTAll tests show that there were no significant differences between groups in AST or ALT after we control for confounding factors.
CONCLUSIONBased on HIS data, there was no evidence to associate the use of Shuxuetong over the recommended dose and effects on liver function.
