Angioedema-like facial swelling as a first manifestation of systemic lupus erythematosus.
- Author:
O Yeong KWON
;
Chang Hee SEO
;
Sung Taek JUNG
;
Dong Ho NAHM
;
Hae Sim PARK
- Publication Type:Original Article
- Keywords:
angioedema fist manifestation of systemic lupus erythematosus
- MeSH:
Angioedema;
Antigen-Antibody Complex;
Complement System Proteins;
Edema;
Female;
Humans;
Inflammation;
Lupus Erythematosus, Systemic*;
Lymphatic Diseases;
Pleural Effusion;
Young Adult
- From:Journal of Asthma, Allergy and Clinical Immunology
1998;18(1):90-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Angioedma is a group of disorders with multifactorial etiology but a similar clinical expression, is characterized by swelling of subcutaneous or submucosal tissue. Systemic lupus erythematosus(SLE) is a chronic multi-systemtic disease characterized by inflammation and tissue damage resulting from deposition of auto-antibodies and immune complex. We experienced a case of angioedema which was the first manifestation of SLE in 24-year-old female patient. She had suffered from severe facial edema and multiple lymphadenopathy for six months and she also had pleural effusion, positive anti-nuclear and anti-DNA antibody test. Marked decrease of C3 and C4 levels was noted with normal antigenic level, and activity of Cl esterase inhibitor. The angioedema was not improved with anti-hitamine agents and instead disappeared with use of corticosteroid and non-steroidal anti-inflammatory drugs. Complement levels normalized after corticosteroid treament. We report a case of SLE which initial manifestation was angioedema.
