Expressions of Estrogen Receptor,Progestogen Receptor,Cerb-B2,and Ki67 Index in the Simple Mucinous Carcinoma of the Breast.
- Author:
Peng Li PENG
1
;
Da-chun ZHAO
2
;
Yi-dong ZHOU
1
;
Feng MAO
1
;
Jia-lin ZHAO
1
;
Qiang SUN
1
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma, Mucinous; Breast Neoplasms; Humans; Ki-67 Antigen; Lymphatic Metastasis; Progestins; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies
- From: Acta Academiae Medicinae Sinicae 2015;37(6):720-723
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo approach the expressions of estrogen receptor (ER),progestogen receptor (PR),Cerb-B2,and Ki67 index in simple mucinous carcinoma of the breast and their clinical significance.
METHODSThe clinicopathological data of 72 patients with simple mucinous carcinoma of the breast who were treated in our hospital from 1997 to 2012 were retrospectively studied. Expressions of ER,PR,Cerb-B2,and Ki67 index and their relationship with clinical characteristics were analyzed.
RESULTSNine patients had lymph node metastasis. Expressions of ER,PR,and Cerb-B2 were 77.8%,69.4%,and 3.1%,respectively. The expressions of ER,PR,and Cerb-B2 showed no correlation with age,menstrual status,and axillary lymph node metastasis (P>0.05). The expression of ER was correlated with tumor diameter (P=0.008) while the expression of PR and Cerb-B2 showed no such correlation.
CONCLUSIONSHigh ER or PR expression and low Cerb-B2 expression predict good prognosis in patients with simple mucinous carcinoma of the breast. Combined detection of ER,PR,Cerb-B2,and Ki67 index may help to improve the multidisciplinary management of simple mucinous carcinoma of the breast.
