Prognostic Superiority of Log Odds of Positive Lymph Nodes in Stage 3 Colorectal Cancer.
10.3881/j.issn.1000-503X.2016.03.009
- Author:
Min-er ZHONG
1
;
Lai XU
2
;
Qiong XU
3
;
Wu-yang JI
2
;
Bei-zhan NIU
2
;
Hui-zhong QIU
2
;
Bin WU
2
Author Information
1. 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
2. 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
3. 2Department of Laboratory,Yunyang Traditional Chinese Medical Hospital,Chongqing 404500,China
- Publication Type:Journal Article
- MeSH:
Colorectal Neoplasms;
diagnosis;
pathology;
Disease-Free Survival;
Humans;
Lymph Nodes;
pathology;
Lymphatic Metastasis;
diagnosis;
Multivariate Analysis;
Neoplasm Staging;
Prognosis;
Retrospective Studies;
Survival Rate
- From:
Acta Academiae Medicinae Sinicae
2016;38(3):294-299
- CountryChina
- Language:English
-
Abstract:
Objective To evaluate the prognostic value of the log odds of positive lymph nodes (LODDS) in stage 3 colorectal cancer (CRC) patients who have undergone curative resection. Methods We performed a retrospective review of 175 stage 3 CRC patients who underwent curative resection in Peking Union Medical College Hospital from 2005 to 2012. Patients were categorized respectively according to the AJCC/UICC N grade,the metastatic lymph node ratio (LNR),and the ratio of their LODDS. The relationship between the N grade,LNR,LODDS,and overall survival (OS) rates were assessed.Results The five-year disease-free survival (DFS) was significantly different among stage 3 CRC patients in different N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=14.9,P=0.001). Univariate analysis showed that TNM stage (Χ(2)=27.0,P=0.000),cancerous node(Χ(2)=3.6,P=0.040),N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=30.4,P=0.000) were related to OS. Multivariate analysis indicated that TNM stage (HR:1.84,95%CI:1.59～6.29,P=0.001) and LODDS classification (HR:1.34,95%CI:1.01～1.80,P=0.047) were independent prognostic factors for OS in stage 3 CRC patients. Conclusion LODDS is a good prognostic indicator in stage 3 CRC patients who have undergone curative resection.
