Association of TNF-alpha and IL-13 genes polymorphisms with bronchial asthma.
10.3760/cma.j.issn.1003-9406.2015.05.022
- VernacularTitle:TNF-α及IL-13基因的多态性与哮喘的相关性研究
- Author:
Wenhua LIANG
1
,
2
;
Zhaoshan ZHOU
;
Zhongqiang JI
;
Yanqing WANG
;
Weilin XUE
;
Xiaoyan ZHANG
Author Information
1. Department of Pneumology, Department of Cardiology, Qingdao Hiser Medical Center, Qingdao, Shangdong 266033, P.R. China. Email: at_mountain@
2. com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Asthma;
genetics;
Female;
Humans;
Interleukin-13;
genetics;
Male;
Middle Aged;
Polymorphism, Single Nucleotide;
Tumor Necrosis Factor-alpha;
genetics
- From:
Chinese Journal of Medical Genetics
2015;32(5):707-710
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To assess the association of polymorphisms of TNF-alpha gene (rs1799724, rs1800630, rs1799964 and rs769178) and IL-13 gene (rs2158177 and rs1295687) with susceptibility to asthma among ethnic Chinese in Qingdao region. METHODS For 400 asthma patients and 200 healthy subjects, above polymorphisms were detected with a SNaPshot method. RESULTS For rs2158177, the frequency of genotype of GG in the asthma group was significantly lower than the control group (2.8% vs. 5%, OR = 0.31, 95%CI: 0.12-0.82, P = 0.021). No significant difference was detected in the genotypic frequencies for the remaining 5 polymorphisms between the two groups (All P > 0.05). CONCLUSION The study has indicated that rs2158177 polymorphism of the IL-13 gene is associated with asthma in ethnic Han Chinese from Qingdao. No association has been found between polymorphisms of TNF-alpha gene with susceptibility to asthma.
