Effect of a lithium-doped calcium phosphate cement in promoting tibial bone defect repair in rats.
- Author:
Li LI
1
,
2
;
Yong-Bao QIN
;
Gang MA
;
Bing LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Cements; chemistry; Calcium Phosphates; chemistry; Female; Lithium; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Tibia; pathology
- From: Journal of Southern Medical University 2016;36(6):824-828
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects a lithium chloride-doped calcium phosphate cement (Li/CPC) on promoting tibial defect repair in rats.
METHODSTwenty 6-month-old female SD rats randomized into Li/CPC (n=10) and CPC control (n=10) groups. Surgery was performed to create bone defects at the bilateral tibia, which were filled with either of the cement. Five rats from each group were sacrificed at 1 and 2 months after the surgery for micro-CT examination and HE staining of the tibia.
RESULTSMicro-CT showed better repair of bone defects in Li/CPC group, which had a significantly higher new bone volume fraction (BV/TV) and a lower trabecular separation/spacing (Tb.Sp) than the control group (P<0.05). HE staining showed an earlier appearance of fiber and osteoid callus in Li/CPC group than CPC control group. The number and quality of bone healing was significantly higher in Li/CPC group than in CPC group.
CONCLUSIONLi/CPC possessed better osteoinductivity and can significantly promote bone defect repair in rats.
