Impact of operative and peri-operative factors on the long-term prognosis of primary liver cancer patients undergoing hepatectomy.
10.1007/s11596-016-1619-2
- Author:
Li-Ning XU
1
;
Ying-Ying XU
2
;
De-Wei GAO
3
Author Information
1. Department of General Surgery, Clinical Division of South Building, Chinese PLA General Hospital, Beijing, 100853, China.
2. Department of Internal Medicine, Henan Cancer Hospital, Zhengzhou, 450003, China.
3. Department of General Surgery, Clinical Division of South Building, Chinese PLA General Hospital, Beijing, 100853, China. chaoyue528@sohu.com.
- Publication Type:Journal Article
- Keywords:
hepatectomy;
influencing factors;
perioperative time;
primary liver cancer;
prognosis
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Hepatocellular;
blood;
pathology;
surgery;
virology;
Cholangiocarcinoma;
blood;
pathology;
surgery;
virology;
Disease-Free Survival;
Female;
Hepatectomy;
adverse effects;
Hepatitis B Surface Antigens;
blood;
Hepatitis B virus;
isolation & purification;
pathogenicity;
Humans;
Liver Neoplasms;
blood;
pathology;
surgery;
virology;
Male;
Middle Aged;
Postoperative Complications;
blood;
pathology;
Prognosis
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2016;36(4):523-528
- CountryChina
- Language:English
-
Abstract:
This study examined the impact of the operative and peri-operative factors on the long-term prognosis of patients with primary liver cancer undergoing hepatectomy. A total of 222 patients with primary liver cancer who underwent hepatectomy were followed up from January 1986 to December 2010 at Chinese PLA General Hospital. The post-operative complication rate was 14.0% for all cases, 13.7% for hepatocellular carcinoma (HCC), 10.0% for cholangiocarcinoma. The 1-, 3-, 5- and 10-year overall survival rates in patients with primary liver cancer after resection were 76.6%, 57.6%, 41.4%, and 21.0%. The survival rates were significantly higher in the HCC group than in the cholangiocarcinoma group (P=0.000), in the non-anatomical resection group than in the anatomical resection group (P=0.005), in the female group than in the male group (P=0.002), in patients receiving no blood transfusion than in those who were given intra-operative blood transfusion (P=0.000), in patients whose intra-operative blood loss was less than 400 mL than in those who intra-operatively lost more than 400 mL (P=0.000). No significant difference was found in the survival rate between the HBsAg-positive group and the HBsAg-negative group (P=0.532). Our study showed that anatomical resection, blood loss and blood transfusion were predictors of poor survival after hepatectomy for primary liver cancer patients, and concomitant hepatitis B virus infection bore no relation with the post-resection survival.
