A study on HLA-DQB1 allele associated with genetic susceptibility to duodenal ulcer in Guangdong Hans.
- Author:
Yi-ping DU
1
;
Hong-jun YE
;
Xia LONG
;
Jie YU
;
Jia-zhi FANG
;
Jun-ping WANG
;
Feng-wen HAO
;
Li JIANG
;
Yuan-yuan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alleles; Asian Continental Ancestry Group; genetics; China; Duodenal Ulcer; ethnology; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; HLA-DQ Antigens; genetics; HLA-DQ beta-Chains; Humans; Male; Membrane Glycoproteins; genetics; Middle Aged; Polymerase Chain Reaction; Young Adult
- From: Chinese Journal of Medical Genetics 2006;23(4):440-442
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the genetic susceptibility of HLA-DQB1 alleles to duodenal ulcer in Chinese Hans from Guangdong area around.
METHODSHundred and five patients with duodenal ulcer and hundred and five healthy controls were examined for HLA-DQB1 genotypes. HLA-DQB1 allele typing was carried out by polymerase chain reaction with sequence specific primers (PCR-SSP).
RESULTSThe allele frequency of HLA-DQB1*0602 in patients with duodenal ulcer (64.8%) was significantly higher than that in healthy controls (14.3%).
CONCLUSIONThese findings suggest that HLA-DQB1*0602 is a susceptible gene to duodenal ulcer in Guangdong Hans of China. And at HLA-DQB1 site, there are immunogenetic differences between duodenal ulcer patients and healthy controls.
