Effects of volatile oil of Rhizoma zingiberis and other two kinds of volatile oil on percutaneous penetration of bullatine A via hairless mouse skin in vitro.
- Author:
Yi-Cen BAI
1
;
Yan-Jie LI
;
Yun-Shu MA
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Animals; Chromatography, High Pressure Liquid; methods; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; pharmacology; Male; Mice; Mice, Nude; Oils, Volatile; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Skin; drug effects; metabolism; Skin Absorption; drug effects
- From: China Journal of Chinese Materia Medica 2008;33(5):513-516
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of volatile oils of Rhizoma Acori Tatarinowii (RAT), Semen Myristicae (SM) and Pericarpium Citri Reticulatae (PCR) on percutaneous penetration of bullatine A via hairless mouse skin in vitro.
METHODBy an improved Franz diffusion, the effects of three kinds of volatile oils on the percutaneous penetration of bullatine A were observed and compared with Azone, and the cumulative amount of bullatine A was determined by HPLC.
RESULTThe penetration enhancement ratios of bullatine A with 7% volatile oil RAT and SM, 5% volatile oil of PCR and 3% Azone were 6.52, 6.74, 2.18, 6.03, respectively.
CONCLUSIONThe volatile oil of RAT, SM and PCR enhance permeation of bullatine A, effectively.
