Role of platelet-derived growth factor in the pathogenesis of preeclampsia.
- Author:
Hui MENG
1
;
Fu-Fan ZHU
;
Chen-Hong WANG
;
Gen-Xiu XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Decidua; blood supply; Female; Gene Expression Regulation; Humans; Platelet-Derived Growth Factor; genetics; metabolism; Pre-Eclampsia; blood; genetics; metabolism; pathology; Pregnancy; Proto-Oncogene Proteins c-sis; RNA, Messenger; genetics; metabolism
- From: Journal of Southern Medical University 2007;27(8):1274-1276
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the role of platelet-derived growth factor (PDGF) in the pathogenesis of preeclampsia (PRE).
METHODSThirteen normal and 20 PRE late-pregnancy women were enrolled in this study. The serum PDGF-BB levels were measured with enzyme-linked immunosorbent assay, and the expression of PDGF-B mRNA in the decidual blood vessel was determined using in situ hybridization.
RESULTSPDGF-BB levels in PRE group was significantly higher than that in normal pregnant women (83.54 -/+34.52 vs 39.61-/+18.20, P<0.001), and the expression of PDGF-B mRNA in decidual blood vessel was also significantly higher in PRE group (P<0.001), showing a positive correlation between serum PDGF and PDGF-B mRNA expression (r=0.603, P<0.001).
CONCLUSIONPDGF is associated with the pathology of decidual blood vessel. Elevated serum PDGF levels and PDGF-B mRNA expression in the decidual blood vessel may play an important role in the pathogenesis of PRE.
