Two Cystic Cavernous Angiomas after Radiotherapy for Atypical Meningioma in Adult Woman : Case Report and Literature Review.
10.3340/jkns.2014.55.1.40
- Author:
Andrea Gennaro RUGGERI
1
;
Pasquale DONNARUMMA
;
Angelo PICHIERRI
;
Roberto DELFINI
Author Information
1. Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome, Rome, Italy. padonnarumma@hotmail.it
- Publication Type:Case Report
- Keywords:
Cavernoma;
Cavernous angioma;
Cavernoma post-radiotherapy;
Radiation therapy;
Cystic cavernoma
- MeSH:
Adult*;
Brain;
Child;
Diagnosis;
Female;
Follow-Up Studies;
Headache;
Hemangioma, Cavernous*;
Humans;
Magnetic Resonance Imaging;
Medulloblastoma;
Meningioma*;
Radiotherapy*;
Radiotherapy, Adjuvant;
Recurrence
- From:Journal of Korean Neurosurgical Society
2014;55(1):40-42
- CountryRepublic of Korea
- Language:English
-
Abstract:
A correlation between radiation therapy and cavernoma has been suspected since 1994. Since then, only a few cases of radio-induced cavernomas have been reported in the literature (85 patients). Most of them were children, and the most frequent original tumour had been medulloblastoma. The authors report a case of two cystic cavernous angiomas after radiation therapy for atypical meningioma in adult woman. This is the first case of cavernous angioma after radiotherapy for low grade meningioma. A 39-year-old, Latin american woman was operated on for a frontal atypical meningioma with intradiploic component and adjuvant radiotherapy was delivered (6000 cGy local brain irradiation, fractionated over 6 weeks). Follow-up MR imaging showed no recurrences of the tumour and no other lesions. Ten years later, at the age of 49, she consulted for progressive drug-resistant headache. MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole. Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma. This is the first case of cavernous angioma after radiation therapy for atypical meningioma : it confirms the development of these lesions after standard radiation therapy also in patients previously affected by non-malignant tumours.
