Changes of insulin-like growth factor-I in focal cerebral ischemical reperfusion injury in rats.
- Author:
Hong-ying WU
1
,
2
;
Jiang-zhong FAN
;
Ren LUO
;
Chuan LI
;
Yi WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Immunohistochemistry; Infarction, Middle Cerebral Artery; metabolism; pathology; Insulin-Like Growth Factor I; biosynthesis; Ischemic Attack, Transient; metabolism; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; metabolism
- From: Journal of Southern Medical University 2008;28(4):598-599
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of insulin-like growth factor-I (IGF-I) in focal cerebral ischemical reperfusion injury model.
METHODSFocal cerebral ischemia was induced in rats using filament method, and the expressions of IGF-I was detected with immunohistochemical staining.
RESULTSThe expression of IGF-I was very low in normal brain tissues, but increased in the infracted area and penumbra after cerebral ischemia. The expressions of IGF-I reached the peak level of 14.83-/+0.48 at days 3 after reperfusion.
CONCLUSIONFocal cerebral ischemia reperfusion injury enhances the expression of endogenous IGF-I.
