Preparation and characterization of non-ionic surfactant vesicle of cantharidin.

Hui LI; Qingying FANG; Hong ZHANG; Chen ZANG; Baoxian ZHANG; Qixia NIE; Guohua WANG

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Preparation and characterization of non-ionic surfactant vesicle of cantharidin.

Author: Hui LI ¹ ; Qingying FANG ; Hong ZHANG ; Chen ZANG ; Baoxian ZHANG ; Qixia NIE ; Guohua WANG
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1. Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China.
Publication Type:Journal Article
MeSH: Cantharidin; administration & dosage; chemistry; isolation & purification; Chromatography, High Pressure Liquid; Drug Delivery Systems; Liposomes; administration & dosage; chemistry; Particle Size; Surface-Active Agents; administration & dosage
From: China Journal of Chinese Materia Medica 2010;35(19):2546-2550
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the preparation of cantharidin entrapped non-ionic surfactant vesicle (noisome)and evaluate its quality.
METHODThe niosome loaded with cantharidin was prepared using injection method by non-ionic surfactants as the carrier. An centrifugation separation method and HPLC analysis method of the cantharidin were established to detect the entrapment efficiency. The optimum preparation technology was established by a orthogonal experiment. The morphology, and particle size were studied to evaluate the preparation.
RESULTThe average size of niosomes were (209. 8 +/- 0.5) nm. The entrapment efficiency of the CTD-NS was (27.5% +/- 2.0%) and Zeta potential was (41.5 +/- 0.65) mV.
CONCLUSIONThe preparation of cantharidin noisome by TweenA and SpanB is practicable and successful. These experiments can be the basement of developing targeting drug delivery system.